Epigenetically modified canicross activities.

Vivid post-exhaustion philisophy.

It is the terminal end of the running-season on snow-covered trails. It isApril 17^th and an anticipated thawing season has begun. Once a year I like to test my physical condition by running an insanely exhausting track. It starts off ascending steep, then increasingly becoming steeper and steeper until reaching the top. Usually I have no hope in my age to expect any progression, however I want to be able to confirm that my capacity for running hasnt declined. Today I took the test, a sunny day with a mild wind that gave me the courage to do some extravaganza after a long winter. Nia and Ulv were my running-mates on this trip. Unlike my other wolfdogs who seem to settle on an even trotting speed which they are unwilling to change, Nia and Ulv can be encouraged to both brake and increase the speed during a run. They have a little «husky-mentality» in that sense. The track starts climbing uphill already at the first steps. Usually before reaching the top my thighs ache, my lips become cyanotic, my vision become blurred, then dizziness and a slight nausea makes a final addition to the exhausted feeling. After reaching the top we continue downhill on the other side reaching the lowest point of the trail only to make a similar return back again.

Fascinated by the new science of epigenetics I have done an experiment on myself lately. For a year I have been running only in a catabolic state, which means no less than 6 hours after the last meal. The last meal never exceeds 15% of energy derived from glucose. In this way I deprive myself of the glucogen stores over several weeks. As a result I must fuel my muscles with fatty acids during a run. Theoretically such stress to the metabolic entities in the cells will lead to both intracellular and extracellular adaptations. Many of which are epigentically changes in gene expression following by transcriptions. Both enzyme production, number and size of mitochondria and increased blood supply in my fatty tissue are controlled by genes and can be changed through this adaptations.

Now, back to my run today. Reaching the top this year with the usual ache in my legs, but without the blurred vision, the dizziness and nausea. Downhill on the other side seemed a little odd as I felt very light in my body. Returning for the top the second time I felt surprisingly at ease. Descending the final downhill was «euphoric» experience. For the first time in years I had improved on this sadistic run. Noramlly I would be stiff and painful arriving home unable to walk normally, but today my vivid mind decided on another run with the other pair of wolfdogs. We jogged an easy trail singing joyfully at the same time. No pains, no exhaustion and a very happy psyche!

During this recovery run my mind also started to run with thoughts on epigenetic changes in our wolfdogs. One of my wolfdog litters produced 2 pups with inferior screeing results for dysplastic hips. However both parents and all four grandparents had excellent hips. Many disease processes beleived to be of genetic origin are now seen in the light of epigenetics. Epigenetic mechanisms that alter gene expression without affecting DNA sequence are now recognized as being of great importance in our understanding of disease susceptibility. Methylation of DNA, modification of histones, and interfering microRNA collectively represents a cadre of epigenetic elements dysregulated in chronic diseases. This is specially true in polygenetically controlled processes such as hip dysplasia in dogs. What can affect the development of a wolfdogs hips during its development? The wolf was developed for running in the forests and wilderness. Not at all on a paved road. The wolf was developed to thrive on nourishment like prey animals with food frequency like once every 3d day! What happens when a wolfdog puppy deprived of enough natural exercise in rough terrain and instead is walked on a lead on a paved road? Consider the importance of stress and the reaction to stress as a stimuli for full growth. The scientific publication «Nature» publised a review on a research on the ability to metabolize starch in either dogs and wolves. The research concludes that one of the genetically adaptations the domestic dogs have developed is its ability to digest and metabolize starch. On the contrary the wolf lack the enzymes necessary to utilize this food source. Can we then expect to be safe with feeding our dogs of recent wolfblood commercial dogfood consisting of a huge percentage of starch ? And again; how does this affect the development of the tissues around the dogs hips? We know that in humans the improper digestion of certain carbohydrates can leads to inflammation and systemic diseases. Maybe we must search for more than genes and breeding in our approach to prevent such ailments as dysplastic hips in our dogs.